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Feline Morbillivirus Infection in Domestic Cats: What Have We Learned So Far?

Eliana De Luca1, Giuseppe Andrea Sautto2, Paolo Emidio Crisi3

  • 1Istituto Zooprofilattico Sperimentale dell'Abruzzo e Molise (IZSAM), 64100 Teramo, Italy.

Viruses
|April 30, 2021
PubMed

Insights

Feline morbillivirus (FeMV) is a global feline pathogen. This review summarizes FeMV infection, exploring its genetic diversity, epidemiology, and pathogenicity, particularly its controversial link to feline chronic kidney disease.

Area of Science:

  • Veterinary Virology
  • Feline Infectious Diseases

Background:

  • Feline morbillivirus (FeMV) was first identified in 2012 and has since been reported globally in domestic cats.
  • Tubulointerstitial nephritis (TIN), a key feature of feline chronic kidney disease (CKD), is a common pathology in feline medicine.
  • A potential link between FeMV infection and TIN remains controversial and unproven.

Purpose of the Study:

  • To review current knowledge on FeMV infection in cats.
  • To explore FeMV's genetic diversity, epidemiology, and pathogenicity.
  • To summarize clinicopathological findings in naturally infected cats.

Main Methods:

  • This review synthesizes existing literature on FeMV.
  • It examines studies on FeMV epidemiology and genetic diversity.
  • It analyzes reported clinicopathological findings and pathogenicity data.

Main Results:

  • FeMV has a global distribution in domestic cats.
  • Research has focused on FeMV's epidemiology and potential role in CKD.
  • The pathogenicity of FeMV and its definitive association with TIN are still unclear.

Conclusions:

  • Further research is needed to clarify FeMV pathogenicity.
  • Understanding FeMV's role in feline kidney disease requires more investigation.
  • A definitive link between FeMV and TIN in cats requires robust scientific evidence.
Keywords:
diagnosisepidemiologyfeline morbillivirusgenetic heterogeneitykidney diseasetropism

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