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Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
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Ischemic Etiology and Prognosis in Men and Women with Acute Heart Failure

Lourdes Vicent1, Jose Guerra2,3, Rafael Vazquez-García4

  • 1Cardiology Department, Hospital Universitario 12 de Octubre, 28028 Madrid, Spain.

Journal of Clinical Medicine
|April 30, 2021
PubMed

Insights

Ischemic heart disease does not increase mortality risk in heart failure (HF) patients. However, diabetes in women and previous readmissions or COPD in men with ischemic HF are linked to poor prognosis.

Area of Science:

  • Cardiology
  • Clinical Research
  • Epidemiology

Background:

  • Coronary heart disease is a frequent comorbidity in heart failure (HF).
  • Understanding the impact of ischemic etiology on HF prognosis in different sexes is crucial for targeted treatment strategies.

Purpose of the Study:

  • To investigate the association between ischemic etiology and 12-month mortality in men and women with heart failure.
  • To identify sex-specific risk factors for poor prognosis in patients with ischemic heart failure.

Main Methods:

  • Prospective, national, multicenter registry study.
  • Enrollment of 1830 heart failure patients, stratified by sex and ischemic etiology.
  • Primary endpoint: 12-month mortality, with secondary analysis of risk factors.

Main Results:

  • Ischemic etiology was more prevalent in men (41.6%) than women (22.2%).
  • Ischemic etiology was not significantly associated with increased 12-month mortality in either sex (p > 0.05 for interaction).
  • Poor prognosis in ischemic heart failure was associated with diabetes in women (HR 2.23) and previous readmissions (HR 1.15) or COPD (HR 1.20) in men.

Conclusions:

  • Ischemic etiology alone does not confer a higher mortality risk in heart failure patients.
  • Sex-specific factors, including diabetes in women and prior readmissions or COPD in men, are critical predictors of outcomes in ischemic heart failure.

Keywords:
heart failureischemic heart diseasemortality

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