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Correlation between predicted and measured digoxin serum concentrations
O S Tayeb1, A M Al-Fares, Y M el-Sayed
1Faculty of Medicine and Allied Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
Journal of Clinical Pharmacy and Therapeutics
|April 1, 1988
Summary
Predicting digoxin serum concentration using creatinine clearance and individual dose is effective. This method accurately estimates patient digoxin levels, aiding in appropriate dosing and avoiding under- or overdosing.
Area of Science:
- Pharmacokinetics
- Clinical Chemistry
Background:
- Digoxin serum concentration measurement guides patient-specific dosing.
- Accurate prediction of digoxin levels is crucial for therapeutic efficacy and safety.
Purpose of the Study:
- To predict digoxin serum concentration in patients.
- To evaluate the utility of creatinine clearance and individual digoxin dose for prediction.
Main Methods:
- Creatinine clearance determined by Cockroft and Gault method.
- Digoxin clearance determined by Scheiner's method.
- Predicted steady-state serum concentration calculated using pharmacokinetic principles.
- Digoxin serum levels measured using fluorescence polarization immunoassay (FPIA).
Main Results:
- Linear regression analysis showed a strong correlation (r=0.9600) between predicted and measured digoxin levels.
- The prediction method yielded a slope of 0.9463 and an intercept of 0.0950.
- The method demonstrated high accuracy in predicting serum concentrations.
Conclusions:
- The developed method is highly useful for predicting digoxin serum levels.
- Accurate prediction aids in managing patients with digoxin therapy, preventing under- or overdosing.