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Related Experiment Videos

Correlation between predicted and measured digoxin serum concentrations.

O S Tayeb1, A M Al-Fares, Y M el-Sayed

  • 1Faculty of Medicine and Allied Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.

Journal of Clinical Pharmacy and Therapeutics
|April 1, 1988
PubMed
Summary

Predicting digoxin serum concentration using creatinine clearance and individual dose is effective. This method accurately estimates patient digoxin levels, aiding in appropriate dosing and avoiding under- or overdosing.

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Area of Science:

  • Pharmacokinetics
  • Clinical Chemistry

Background:

  • Digoxin serum concentration measurement guides patient-specific dosing.
  • Accurate prediction of digoxin levels is crucial for therapeutic efficacy and safety.

Purpose of the Study:

  • To predict digoxin serum concentration in patients.
  • To evaluate the utility of creatinine clearance and individual digoxin dose for prediction.

Main Methods:

  • Creatinine clearance determined by Cockroft and Gault method.
  • Digoxin clearance determined by Scheiner's method.
  • Predicted steady-state serum concentration calculated using pharmacokinetic principles.
  • Digoxin serum levels measured using fluorescence polarization immunoassay (FPIA).

Main Results:

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  • Linear regression analysis showed a strong correlation (r=0.9600) between predicted and measured digoxin levels.
  • The prediction method yielded a slope of 0.9463 and an intercept of 0.0950.
  • The method demonstrated high accuracy in predicting serum concentrations.

Conclusions:

  • The developed method is highly useful for predicting digoxin serum levels.
  • Accurate prediction aids in managing patients with digoxin therapy, preventing under- or overdosing.