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The Current Landscape of Clinical Trials for Systemic Treatment of HCC

Friedrich Foerster1, Peter Robert Galle1

  • 1First Department of Medicine, University Medical Center of the Johannes Gutenberg University Mainz, D-55131 Mainz, Germany.

Cancers
|April 30, 2021
PubMed

Insights

Systemic treatments for advanced liver cancer (hepatocellular carcinoma) are rapidly evolving. Combination therapies, like atezolizumab and bevacizumab, show promise, changing treatment strategies and improving outcomes.

Area of Science:

  • Hepatobiliary cancers
  • Medical oncology
  • Clinical trial research

Background:

  • Systemic treatment for hepatocellular carcinoma (HCC) has seen recent advancements.
  • Previous trials with PD1-inhibitors as monotherapy in advanced HCC failed.
  • New combination therapies are emerging, offering new hope.

Purpose of the Study:

  • To review the evolving landscape of clinical trials for systemic HCC treatments.
  • To provide clarity on current and emerging therapeutic strategies.
  • To cover various treatment lines, stages, and immunotherapies.

Main Methods:

  • Comprehensive review of ongoing clinical trials in hepatocellular carcinoma.
  • Analysis of systemic treatments including combination therapies and immunotherapies.
  • Categorization of trials by treatment line (first/second line, intermediate), and strategy (adjuvant/neoadjuvant).

Main Results:

  • The combination of atezolizumab and bevacizumab demonstrates positive results in first-line advanced HCC.
  • This combination is poised to alter HCC management and encourage further combination therapies.
  • Numerous trials are investigating diverse systemic agents and immune interventions.

Conclusions:

  • The field of systemic HCC treatment is dynamic, with combination therapies showing significant promise.
  • Ongoing clinical trials are exploring a wide range of strategies beyond immune checkpoint inhibition.
  • Atezolizumab and bevacizumab combination marks a significant shift in advanced HCC treatment.
Keywords:
combination therapydrugsimmunotherapyliver cancertherapy

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