Lipidic Matrixes Containing Clove Essential Oil: Biological Activity, Microstructural and Textural Studies
John Rojas1, Sergio Cabrera1, Julie Benavides2
1College of Pharmaceutical and Food Sciences, University of Antioquia, University Campus, Calle 67 No. 53-108, Medellín 050010, Colombia.
Molecules (Basel, Switzerland)
|April 30, 2021
Summary
Natural waxes stabilize clove essential oil (CEO) for topical applications. Beeswax and ozokerite wax matrixes offer superior antioxidant and textural properties due to their crystalline structure.
Area of Science:
- Materials Science
- Pharmaceutical Sciences
- Natural Products Chemistry
Background:
- Clove essential oil (CEO) possesses potent antioxidant and antimicrobial properties.
- The therapeutic efficacy of CEO is limited by the poor stability of its active compounds when exposed to light and temperature.
- Developing stable formulations is crucial for harnessing the full potential of CEO in various applications.
Purpose of the Study:
- To evaluate the textural, antioxidant, antimicrobial, and microstructural properties of matrixes formulated with natural waxes and CEO.
- To investigate the influence of different natural waxes on the characteristics of CEO-loaded matrixes.
- To assess the suitability of these lipidic matrixes for topical applications.
Main Methods:
- Formulation of matrixes using beeswax, candelilla wax, carnauba wax, and ozokerite wax loaded with CEO.
- Comprehensive characterization including thermal analysis, microstructural examination, textural analysis, wetting studies, antioxidant assays, antimicrobial testing, and infrared spectroscopy.
- Evaluation of crystal morphology and structural organization within the wax matrixes.
Main Results:
- The chemical composition of waxes (e.g., wax esters, fatty acids, hydrocarbons) significantly influenced wetting, texture, melting, and crystallization behavior.
- Matrixes formed with beeswax and ozokerite wax exhibited needle-like crystal structures, leading to enhanced matrix strength, adhesion, and plasticity compared to carnauba and candelilla wax matrixes.
- All studied matrix systems maintained an orthorhombic crystal allomorph despite variations in crystal shape (grainy, oval, needle-like).
Conclusions:
- Natural waxes can effectively stabilize clove essential oil, improving its properties for topical use.
- Beeswax and ozokerite wax matrixes demonstrate superior textural and mechanical properties, making them promising candidates for stable CEO formulations.
- The developed lipidic matrixes show potential for topical applications, offering acceptable antioxidant and textural characteristics.
Keywords:
antioxidant and antimicrobial propertiesclove essential oilcosmetic lipidic matrixesmechanical and wetting propertiesMore Related Videos
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