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Updated: Nov 7, 2025

Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo
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Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo

Published on: September 18, 2014

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Functional Interfaces, Biological Pathways, and Regulations of Interferon-Related DNA Damage Resistance Signature

Monikaben Padariya1, Alicja Sznarkowska1, Sachin Kote1

  • 1International Centre for Cancer Vaccine Science, University of Gdansk, ul. Kładki 24, 80-822 Gdansk, Poland.

Biomolecules
|April 30, 2021
PubMed

Insights

Interferon-related DNA damage resistant signature (IRDS) genes promote cancer resistance to therapy. Targeting these IRDS genes may resensitize tumors, improving anti-cancer treatment outcomes.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Interferon-related DNA damage resistant signature (IRDS) genes are upregulated in cancers, conferring resistance to chemotherapy and radiotherapy.
  • These genes are part of the larger interferon-stimulated genes (ISGs) family and are influenced by viral infections.

Purpose of the Study:

  • To review the role of IRDS genes in cancer therapy resistance.
  • To explore strategies for targeting IRDS genes to enhance treatment sensitivity.
  • To identify upstream regulators and functional interactions of IRDS genes.

Main Methods:

  • Literature review of IRDS genes, their regulation by interferons (IFNs), and their association with biological pathways.
  • Analysis of viral effects on IRDS genes and strategies to suppress them.
  • Identification of pharmacophore models for IRDS protein interactions with biomolecules.

Main Results:

  • IRDS genes, including STAT1, IRF7, OAS family, and BST2, contribute to chemo- and radioresistance.
  • Specific IRDS genes are frequently associated with pathways involving IFIT1/3, IFITM1, ISG15, MX1/2, and OAS1/3/L.
  • Pharmacophore models reveal interactions of IRDS proteins with DNA, RNA, GDP, and NADP+, with Lysine commonly involved in ATP binding.

Conclusions:

  • Targeting IRDS genes represents a promising strategy to overcome cancer therapy resistance.
  • Understanding IRDS gene function and interactions can lead to novel therapeutic approaches for cancer treatment.
Keywords:
ATPDNADNA damageIRDS genesRNAchemotherapy and radiotherapyfunctional siteinterferonprotein interfacesreceptorsresistanceupstream regulatorviruses

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