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Low-dose acebutolol given once daily in the treatment of chronic angina pectoris

I L Piña1, E V Smith, D J Weidler

  • 1Division of Cardiology, University of Miami School of Medicine, Florida.

Journal of Clinical Pharmacology
|May 1, 1988
PubMed

Insights

Once-daily acebutolol effectively manages chronic stable angina pectoris. This beta blocker significantly improved exercise hemodynamics and reduced ST depression without adverse effects.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Acebutolol is a beta-1 selective beta blocker with intrinsic sympathomimetic activity.
  • It is effective for chronic angina pectoris with multiple daily doses.

Purpose of the Study:

  • To evaluate the long-term effects of once-daily acebutolol (400 mg) versus placebo.
  • Assess impact on exercise hemodynamics, ST segment depression, and rate pressure product.

Main Methods:

  • Eleven patients with hypertension and chronic angina pectoris were enrolled.
  • A randomized, placebo-controlled study was conducted.
  • Exercise treadmill tests were used for objective measurements.

Main Results:

  • Once-daily acebutolol significantly reduced peak heart rate, systolic blood pressure, and rate pressure product during exercise.
  • Significant reduction in ST segment depression was observed with acebutolol.
  • No significant adverse effects were reported during the study.

Conclusions:

  • Once-daily acebutolol (400 mg) is efficacious for chronic stable angina pectoris.
  • This dosing regimen improves exercise hemodynamics and reduces ischemic indicators.
  • Acebutolol offers a convenient once-daily treatment option for angina.

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