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Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
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Functionalization of Synthetic Bone Substitutes.

André Busch1,2, Marcus Jäger1,3, Constantin Mayer1

  • 1Department of Orthopedics, Trauma and Reconstructive Surgery, St. Marien Hospital Mülheim an der Ruhr, D-45468 Mülheim, Germany.

International Journal of Molecular Sciences
|April 30, 2021
PubMed
Summary
This summary is machine-generated.

Surface-coated bone substitutes combat implant-related infections and improve bone healing. This review covers current advancements and future directions in functionalized biomaterials for osseous defect treatment.

Keywords:
BMPantibioticsimplant related infectionstissue engineering

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Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Infectious Disease

Background:

  • Bone substitutes are crucial for treating osseous defects.
  • Implant-related infections (IRI) pose a significant challenge in bone regeneration.
  • Functionalized biomaterials offer solutions to prevent IRI and enhance bone healing.

Purpose of the Study:

  • To provide an overview of current surface-coated bone substitutes.
  • To explore the use of antibiotics and osteoinductive substances in bone substitutes.
  • To offer future perspectives on advanced bone regeneration strategies.

Main Methods:

  • Literature review of surface-coated bone substitutes.
  • Analysis of functionalization strategies including antibiotics and osteoinductive agents.
  • Synthesis of current research trends and future outlook.

Main Results:

  • Surface modification of bone substitutes is key to preventing IRI.
  • Combined approaches using antibiotics and osteoinductive factors show promise.
  • Various coating techniques enhance biocompatibility and therapeutic efficacy.

Conclusions:

  • Surface-coated bone substitutes represent a significant advancement in treating osseous defects.
  • Targeted functionalization is essential for mitigating implant-related infections.
  • Future research should focus on novel biomaterials and synergistic therapeutic strategies for enhanced bone regeneration.