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Effectiveness of Bioactive Compound as Antibacterial and Anti-Quorum Sensing Agent from Myrmecodia pendans: An In

Mieke Hemiawati Satari1, Eti Apriyanti2, Hendra Dian Adhita Dharsono3

  • 1Department of Oral Biology, Faculty of Dentistry, Universitas Padjadjaran, Bandung 40132, Indonesia.

Molecules (Basel, Switzerland)
|April 30, 2021
PubMed
Abstract

Insights

This study identified biflavonoid from Myrmecodia pendans as a potential antibacterial agent. Molecular docking revealed its strong binding affinity, suggesting it as a lead compound for new antibiotic development.

Area of Science:

  • Phytochemistry
  • Computational Chemistry
  • Pharmacology

Background:

  • Antibiotic resistance necessitates novel therapeutic strategies and antibacterial agents.
  • Myrmecodia pendans (Sarang Semut) possesses compounds with potential antibacterial activity.
  • The specific protein targets of these compounds, particularly in quorum sensing, remain largely unidentified.

Purpose of the Study:

  • To investigate and predict the mechanism of action of antibacterial compounds from Myrmecodia pendans.
  • To identify specific protein targets for these compounds using molecular docking.
  • To explore the potential of these compounds as novel antibacterial agents.

Main Methods:

  • Eight compounds from Myrmecodia pendans were used as ligands, with antibiotics as positive controls.
  • Ligands were screened for bioactivity using the Prediction of Activity Spectra for Substances (PASS) program.
  • Molecular docking was performed using AutoDock Vina against 12 key bacterial proteins, including penicillin-binding protein and DNA gyrase.

Main Results:

  • Several compounds exhibited significant predicted activity (Pa > 0.5) against cell wall proteins.
  • Biflavonoid (compound 2) demonstrated the strongest binding affinity across most tested proteins.
  • Biflavonoid acts as a non-competitive inhibitor due to binding at only three residues.

Conclusions:

  • Biflavonoid from Myrmecodia pendans shows promise as a lead compound for developing new antibacterial agents.
  • The identified binding interactions provide a basis for further drug design and development.
  • This research contributes to understanding natural product-based strategies against antibiotic resistance.
Keywords:
Myrmecodia pendansanti-bacteriamolecular dockingproteinquorum sensing

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