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Fabrication of Polycaprolactone/Nano Hydroxyapatite (PCL/nHA) 3D Scaffold with Enhanced In Vitro Cell Response via
Yong Sang Cho1, So-Jung Gwak2, Young-Sam Cho3
1Medical IT Convergence Research Section, Daegu-Gyeongbuk Research Center, Electronics and Telecommunications Research Institute (ETRI), Techno Sunhwan-ro 10-gil, Dalseong-gun, Daegu 42994, Korea.
Polymers
|April 30, 2021
Summary
A novel dual-pore kagome structure in 3D-printed scaffolds enhances cell response and mechanical properties. This design, created using design for additive manufacturing (DfAM), offers superior cell adhesion, growth, and ALP concentration compared to conventional patterns.
Area of Science:
- Biomaterials Engineering
- Additive Manufacturing
- Tissue Engineering
Background:
- 3D-printed scaffolds are crucial for tissue regeneration.
- Optimizing scaffold mechanical properties and in vitro cell response is essential.
- Conventional scaffold designs may not fully meet these requirements.
Purpose of the Study:
- To investigate a novel dual-pore kagome-structure design for 3D-printed scaffolds.
- To compare the mechanical properties of this design against conventional and offset patterns.
- To evaluate the in vitro cell response of the proposed scaffold design.
Main Methods:
- Utilizing design for additive manufacturing (DfAM) to create 3D-printed scaffolds with a dual-pore kagome structure.
- Assessing compressive modulus and porosity.
- Evaluating in vitro cell adhesion, cell growth, and alkaline phosphatase (ALP) concentration over 14 days.
Main Results:
- The dual-pore kagome scaffold exhibited mechanical properties comparable to conventional patterns at similar pore sizes, despite higher porosity.
- The kagome structure enhanced compressive modulus compared to conventional and offset patterns at similar porosities.
- Superior cell adhesion, growth, and ALP concentration were observed for the proposed scaffold compared to control groups.
Conclusions:
- Kagome and dual-pore structures, implemented through DfAM, significantly improve 3D-printed scaffold mechanical properties and in vitro cell response.
- The dual-pore structure demonstrates enhanced in vitro cell response compared to conventional and offset patterns.
- This novel design holds promise for advanced tissue engineering applications.
