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New Neuroprotective Effect of Lemon IntegroPectin on Neuronal Cellular Model.

Domenico Nuzzo1,2, Pasquale Picone1,2, Costanza Giardina3

  • 1Istituto per la Ricerca e l'Innovazione Biomedica, CNR, via U. La Malfa 153, 90146 Palermo, Italy.

Antioxidants (Basel, Switzerland)
|April 30, 2021
PubMed
Summary

Newly developed lemon IntegroPectin demonstrates neuroprotective effects in laboratory settings. This pectin, derived from lemon waste, shows promise in protecting neuronal cells from oxidative stress and may aid in combating neurodegenerative diseases.

Keywords:
antioxidantflavonoidshesperidinmitochondrianeurological diseaseneuroprotectiveoxidative stresspectin

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Area of Science:

  • Biochemistry
  • Neuroscience
  • Food Science

Background:

  • Oxidative stress, driven by reactive oxygen species (ROS), significantly damages neuronal cells.
  • This cellular damage is a key factor in the progression of neurodegenerative diseases.
  • Current treatments for neurodegenerative diseases are limited, necessitating novel therapeutic strategies.

Purpose of the Study:

  • To investigate the neuroprotective potential of lemon IntegroPectin derived from organic lemon processing waste.
  • To evaluate the effects of lemon IntegroPectin and commercial citrus pectin on neuronal cells under oxidative stress.
  • To assess cell viability, morphology, ROS production, and mitochondrial function in response to H2O2 treatment.

Main Methods:

  • Utilized hydrodynamic cavitation to extract IntegroPectin from lemon processing waste.
  • Treated human neuroblastoma SH-SY5Y cells with hydrogen peroxide (H2O2) to induce oxidative stress.
  • Assessed cell viability, morphology, ROS levels, and mitochondrial perturbation using various assays.

Main Results:

  • Lemon IntegroPectin exhibited significant neuroprotective activity in vitro.
  • The pectin demonstrated a protective effect against H2O2-induced oxidative stress in neuronal cells.
  • No toxicity was observed for the lemon IntegroPectin, which is rich in adsorbed flavonoids and terpenes.

Conclusions:

  • Lemon IntegroPectin shows considerable promise as a therapeutic agent for neurodegenerative diseases.
  • Further research is warranted to explore its efficacy in preventing or treating neurological conditions.
  • This novel pectic substance represents a potential new avenue for neuroprotection.