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Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
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Updated: Nov 7, 2025

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Structural Changes on MRI Demonstrate Specific Cerebellar Involvement in SLE Patients-A VBM Study.

Johan Mårtensson1, Theodor Rumetshofer2, Jessika Nystedt2

  • 1Department of Clinical Sciences Lund, Logopedics, Phoniatrics and Audiology, Faculty of Medicine, Lund University, 221 00 Lund, Sweden.

Brain Sciences
|April 30, 2021
PubMed
Summary

Systemic lupus erythematosus (SLE) patients show reduced grey matter in the cerebellum compared to healthy individuals. Neuropsychiatric symptoms did not correlate with these specific brain structure differences in SLE patients.

Keywords:
VBMcerebellumlupusneuroimaging

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Area of Science:

  • Neuroimaging
  • Neurology
  • Rheumatology

Background:

  • Systemic lupus erythematosus (SLE) is an autoimmune disease with potential neurological complications.
  • Neuropsychiatric lupus (NPSLE) affects a significant portion of SLE patients, impacting quality of life.
  • Understanding brain structure alterations in SLE is crucial for diagnosis and treatment.

Purpose of the Study:

  • To compare brain structure using T1-weighted MRI between SLE patients and healthy controls (HC).
  • To investigate if brain structure differences are more pronounced in SLE patients with neuropsychiatric symptoms (NPSLE) versus those without (non-NPSLE).

Main Methods:

  • Structural T1-weighted MRI scans were acquired from 69 female SLE patients and 24 age-matched female HC.
  • Neuropsychological assessments were conducted using the CNS Vital Signs test battery.
  • FSL-VBM software was utilized for preprocessing and analyzing T1-weighted images.

Main Results:

  • SLE patients exhibited lower grey matter probability in the bilateral cerebellum (region VIIIa) compared to HC.
  • No significant structural differences in cerebellum region VIIIa were observed between NPSLE and non-NPSLE subgroups.
  • Grey matter values in cerebellum region VIIIa showed a weak positive correlation with psychomotor speed.

Conclusions:

  • Cerebellar grey matter reductions in region VIIIa are associated with SLE, irrespective of neuropsychiatric involvement.
  • The findings support the cerebellum's role in sensorimotor processing, potentially affected in SLE.
  • Further research is needed to elucidate the specific mechanisms linking SLE, brain structure, and cognitive function.