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Prochlorperazine-induced chronic cholestasis.

A S Lok1, I O Ng

  • 1Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong.

Journal of Hepatology
|June 1, 1988
PubMed
Summary
This summary is machine-generated.

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Prochlorperazine can cause prolonged cholestasis, a liver condition, lasting over two years. This case highlights the potential for drug-induced liver injury to mimic primary biliary cirrhosis, necessitating long-term patient monitoring.

Area of Science:

  • Hepatology
  • Clinical Pharmacology
  • Gastroenterology

Background:

  • Drug-induced liver injury (DILI) represents a significant clinical challenge.
  • Cholestatic liver injury can arise from various pharmaceutical agents.
  • Prochlorperazine is an antiemetic medication with known potential hepatotoxicity.

Observation:

  • A case report details a patient experiencing cholestasis attributed to prochlorperazine.
  • The cholestasis persisted for an unusually long duration, exceeding two years.
  • Clinical, biochemical, and histological features were consistent with drug-induced chronic cholestasis.

Findings:

  • Despite jaundice resolution, liver biopsy revealed significant fibrosis.
  • Histological findings included portal tract expansion and bridging fibrosis.

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  • A paucity of inter-lobular bile ducts was noted, mimicking primary biliary cirrhosis.

    • Implications:

    • This case underscores the potential for prochlorperazine to cause chronic cholestatic liver injury.
    • The histological presentation can resemble primary biliary cirrhosis, complicating diagnosis.
    • Extended follow-up is crucial to ascertain the long-term prognosis and risk of cirrhosis progression.