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Venous Malformations and Blood Coagulation in Children
Johanna Aronniemi1,2,3, Satu Långström1,3,4, Katariina A Mattila1,5
1University of Helsinki, Yliopistonkatu 4, 00100 Helsinki, Finland.
Children (Basel, Switzerland)
|April 30, 2021
Summary
Localized intravascular coagulopathy (LIC) is common in pediatric venous malformations (VMs), with abnormal D-dimer and FXIII levels frequently observed. These findings aid in assessing hemostatic complication risks in children with VMs.
Area of Science:
- Pediatric Hematology
- Vascular Malformations
- Coagulation Disorders
Background:
- Venous malformations (VMs) are congenital vascular anomalies.
- VMs are increasingly linked to coagulation abnormalities, forming localized intravascular coagulopathy (LIC).
- Limited data exists on specific coagulation and fibrinolytic parameters in pediatric VM patients.
Purpose of the Study:
- To systematically analyze coagulation and fibrinolytic parameters in pediatric patients with VMs.
- To correlate laboratory findings with clinical and imaging features of VMs.
- To evaluate the prevalence of LIC in this population.
Main Methods:
- Retrospective analysis of 62 pediatric VM patients.
- Detailed laboratory testing of coagulation and fibrinolytic activity.
- Correlation of laboratory results with clinical and MRI data.
Main Results:
- 39% of patients showed elevated D-dimer and 20% decreased FXIII, indicating LIC.
- LIC markers correlated with larger, deeper, and diffuse VMs.
- Elevated FVIII was associated with smaller, superficial VMs; elevated antithrombin was common but unassociated.
Conclusions:
- Localized intravascular coagulopathy (LIC) is prevalent in pediatric venous malformations.
- Findings provide a basis for risk assessment of hemostatic complications.
- Further research is needed on mechanisms and clinical relations of coagulation disturbances.
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