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The Association between Migraine and Abdominal Aortic Aneurysms: A Nationwide Population-Based Cohort Study

Jou-Yu Lin1, Che-Se Tung2, Jen-Chun Wang3

  • 1Department of Rehabilitation, Cheng Hsin General Hospital, Taipei 11220, Taiwan.

International Journal of Environmental Research and Public Health
|April 30, 2021
PubMed

Insights

Migraine patients face a higher risk of developing abdominal aortic aneurysm (AAA). This study found a significant association between migraine and AAA development over a 15-year period.

Area of Science:

  • Cardiovascular epidemiology
  • Neurology
  • Vascular surgery

Background:

  • Migraine is linked to cardiovascular disease risk factors.
  • Shared epidemiological and molecular pathways exist between migraine and abdominal aortic aneurysm (AAA).

Purpose of the Study:

  • To investigate the potential association between migraine and an increased risk of developing AAA.
  • To evaluate the cumulative incidence of AAA in patients diagnosed with migraine.

Main Methods:

  • Nationwide population-based retrospective cohort study using Taiwan's National Health Insurance Research Database (NHIRD).
  • Involved analysis of 1,936,512 patients, with 53,668 diagnosed with migraine.
  • Assessed AAA incidence over a 15-year follow-up period.

Main Results:

  • Patients with migraine showed a significantly higher cumulative risk of developing AAA (3.558) within 5 years.
  • Over 15 years, the incidence of AAA was significantly higher in migraine patients (0.98%) compared to non-migraine patients (0.24%).

Conclusions:

  • A significant association was identified between the development of migraine and abdominal aortic aneurysm.
  • Migraine may be a risk factor for AAA, warranting further investigation into shared mechanisms.
Keywords:
National Health Insurance Research Databaseabdominal aortic aneurysmcardiovascular diseasesmigraine

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