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Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
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Admission High-Sensitive Cardiac Troponin T Level Increase Is Independently Associated with Higher Mortality in

Romaric Larcher1,2, Noemie Besnard3, Aziz Akouz4

  • 1Biochemistry and Hormonology Department, Lapeyronie Hospital, University Hospital of Montpellier, 34090 Montpellier, France.

Journal of Clinical Medicine
|April 30, 2021
PubMed

Insights

High-sensitive cardiac troponin T (hs-cTnT) levels at ICU admission predict in-hospital mortality in critically ill COVID-19 patients. Higher hs-cTnT and lower PaO2/FiO2 independently indicate increased mortality risk.

Area of Science:

  • Cardiology
  • Critical Care Medicine
  • Infectious Diseases

Background:

  • Elevated high-sensitive cardiac troponin T (hs-cTnT) in COVID-19 is linked to adverse outcomes.
  • Prognostic value of hs-cTnT in critically ill COVID-19 patients requires further assessment.

Purpose of the Study:

  • To evaluate the predictability of hs-cTnT for in-hospital mortality in critically ill COVID-19 patients.
  • To assess hs-cTnT as an early risk stratification tool for intensive care unit (ICU) admissions.

Main Methods:

  • Multicenter retrospective cohort study conducted in French ICUs from March to May 2020.
  • Included 111 laboratory-confirmed COVID-19 patients.
  • Assessed in-hospital mortality predictability of hs-cTnT levels at ICU admission.

Main Results:

  • Median hs-cTnT serum levels were 16.0 ng/L at ICU admission.
  • In-hospital mortality was 29% (32/111).
  • Lower PaO2/FiO2 and higher hs-cTnT levels were independently associated with in-hospital mortality.

Conclusions:

  • hs-cTnT levels, along with PaO2/FiO2, can aid in early risk stratification of critically ill COVID-19 patients.
  • hs-cTnT may assist in triage decisions for severe COVID-19 cases.
Abstract

Keywords:
COVID-19ICUSARS-CoV-2high-sensitive cardiac troponin Tmyocardial injuryoutcomes

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