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Cell-Mediated Therapies to Facilitate Operational Tolerance in Liver Transplantation

Samia D Ellias1, Ellen L Larson1, Timucin Taner1,2

  • 1Division of Transplant Surgery, Department of Surgery, Mayo Clinic, Rochester, MN 55905, USA.

International Journal of Molecular Sciences
|April 30, 2021
PubMed

Cell therapies using immune cells or non-parenchymal cells of the liver have emerged as potential treatments to facilitate immunosuppression withdrawal and to induce operational tolerance in liver transplant (LT) recipients. Recent pre-clinical and clinical trials of cellular therapies including regulatory T cells, regulatory dendritic cells, and mesenchymal cells have shown promising results. Here we briefly summarize current concepts of cellular therapy for induction of operational tolerance in LT recipients.

Keywords:
dendritic cellsliver transplantationmesenchymal cellsoperational toleranceregulatory T cellstransplant immunology

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