Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comments to the "Letter to the Editor" for the manuscript titled "Increased expression of inflammasome signaling genes and proteins in selective brain regions in the intermediate stage of Alzheimer's disease".

Brain pathology (Zurich, Switzerland)·2026
Same author

Common Medical Comorbidities, Demographic Factors and Levels of Plasma Biomarkers of Alzheimer's Disease and Neurodegeneration in Black/African American Older Adults.

Biomolecules·2026
Same author

Interleukin-18 as a Potential Biomarker for Radiotherapy-Related Pain in Breast Cancer: Implications for Personalized Pain Management.

Cancers·2026
Same author

Increased expression of inflammasome signaling genes and proteins in selective brain regions in the intermediate stage of Alzheimer's disease.

Brain pathology (Zurich, Switzerland)·2026
Same author

Feasibility Study on Inflammasome Proteins as Biomarkers in the Cerebrospinal Fluid of Pediatric Patients with Hydrocephalus Due to Intraventricular Hemorrhage.

Biomolecules·2026
Same author

Potential Role of Serum Cytokines and Chemokines as Biomarkers of Injury Severity and Functional Outcomes Following Pediatric Traumatic Brain Injury.

Cells·2026

Related Experiment Video

Updated: Nov 7, 2025

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
09:12

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

16.4K

Age-Dependent Microglial Response to Systemic Infection.

Brianna Cyr1, Juan Pablo de Rivero Vaccari1,2

  • 1Department of Neurological Surgery and The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

Cells
|April 30, 2021
PubMed
Summary
This summary is machine-generated.

Inflammation and immune responses change with age. Microglial responses to bacterial infection differ between young and middle-aged mice, indicating age-related variations in brain inflammation.

Keywords:
aginginfectioninflammationmicrogliasepsis

More Related Videos

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility
07:54

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Published on: April 13, 2017

10.1K
Culturing Microglia from the Neonatal and Adult Central Nervous System
11:28

Culturing Microglia from the Neonatal and Adult Central Nervous System

Published on: August 9, 2013

28.4K

Related Experiment Videos

Last Updated: Nov 7, 2025

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
09:12

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

16.4K
Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility
07:54

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Published on: April 13, 2017

10.1K
Culturing Microglia from the Neonatal and Adult Central Nervous System
11:28

Culturing Microglia from the Neonatal and Adult Central Nervous System

Published on: August 9, 2013

28.4K

Area of Science:

  • Neuroimmunology
  • Aging research
  • Infectious disease immunology

Background:

  • Inflammation is a key component of aging, with older individuals exhibiting a more pronounced innate immune response.
  • Systemic infection responses vary significantly with age, impacting overall health and recovery.
  • Microglia, the brain's resident immune cells, play a critical role in neuroinflammation.

Purpose of the Study:

  • To investigate age-related differences in microglial response to systemic infection.
  • To determine if pro- and anti-inflammatory responses by microglia vary with age following bacterial challenge.
  • To comment on the implications of these findings for understanding brain inflammation in aging.

Main Methods:

  • Comparative study using young (2 months) and middle-aged (13-14 months) mice.
  • Systemic infection model using live *Escherichia coli* challenge.
  • Analysis of microglial response, including pro- and anti-inflammatory markers.

Main Results:

  • Microglial response to systemic infection differs between young and middle-aged mice.
  • Age influences the balance of pro- and anti-inflammatory signaling by microglia.
  • The study highlights age-dependent neuroinflammatory dynamics.

Conclusions:

  • The aging process alters microglial reactivity to systemic infection.
  • Understanding age-related changes in neuroinflammation is crucial for developing targeted interventions.
  • This research provides insights into the differential immune surveillance of the aging brain.