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Pathogenesis of Retraction Pocket of the Tympanic Membrane-A Narrative Review

Milan Urík1, Miroslav Tedla2, Pavel Hurník3,4

  • 1Department of Paediatric Otorhinolaryngology, Faculty of Medicine of Masaryk University in Brno, University Hospital Brno, 61300 Brno, Czech Republic.

Medicina (Kaunas, Lithuania)
|April 30, 2021
PubMed

Insights

Inflammation plays a key role in the development and progression of retraction pockets (RP) of the tympanic membrane. New histological and immunohistochemical findings support this crucial role in pathogenesis and progression to cholesteatoma.

Area of Science:

  • Otolaryngology
  • Pathology
  • Inflammation Research

Background:

  • Retraction pockets (RP) of the tympanic membrane are a common condition.
  • Negative middle ear pressure is traditionally considered the primary cause of RP.
  • The role of inflammation in RP development is increasingly recognized.

Purpose of the Study:

  • To review current knowledge on the pathogenesis of tympanic membrane retraction pockets.
  • To investigate the role of inflammation in RP development and progression.
  • To present new histological and immunohistochemical findings supporting the role of inflammation.

Main Methods:

  • A narrative literature review was conducted.
  • Histological analysis of RPs was performed.
  • Immunohistochemical studies of RPs were carried out.

Main Results:

  • Literature review confirms the significant role of inflammation in RP pathogenesis.
  • Histological and immunohistochemical analyses revealed inflammatory markers within RPs.
  • Findings support inflammation as a key factor in RP progression to cholesteatoma.

Conclusions:

  • Inflammation is a critical factor in the pathogenesis of tympanic membrane retraction pockets.
  • Inflammation drives the progression of RPs towards cholesteatoma.
  • New histological and immunohistochemical data corroborate the inflammatory basis of RP.
Keywords:
cholesteatomachronic otitis mediapathogenesispathologyretraction pockettympanic membrane

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