Related Experiment Video

Updated: Nov 7, 2025

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
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Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

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ING Proteins: Tumour Suppressors or Oncoproteins

Karine Jacquet1, Olivier Binda1,2

  • 1Institut NeuroMyoGène (INMG), Université Claude Bernard Lyon 1, Université de Lyon, CNRS UMR 5310, INSERM U 1217, 69008 Lyon, France.

Cancers
|April 30, 2021
PubMed

Insights

The INhibitor of Growth (ING) proteins, initially identified as tumor suppressors, are crucial for normal cell proliferation. These chromatin-associated factors play key roles in cancer development and progression.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Epigenetics

Background:

  • The INhibitor of Growth (ING) family was established in the 1990s with the discovery of ING1, a tumor suppressor.
  • Initial family classification relied on sequence homology.
  • Recent studies reveal ING proteins are essential for normal eukaryotic cell proliferation.

Purpose of the Study:

  • To discuss the multifaceted roles of ING proteins in cellular processes.
  • To explore the involvement of ING proteins in chromatin signaling.
  • To contextualize the function of ING proteins in cancer development and progression.

Main Methods:

  • Literature review and synthesis of existing research on ING proteins.
  • Analysis of the role of plant homeodomain (PHD) in ING protein function.
  • Examination of chromatin signaling pathways involving ING proteins.

Main Results:

  • ING proteins, beyond tumor suppression, are vital for normal cell proliferation in eukaryotes.
  • ING proteins are chromatin-associated factors featuring a plant homeodomain (PHD) for methylated lysine interactions.
  • The roles of ING proteins in chromatin signaling are implicated in cancer.

Conclusions:

  • ING proteins have diverse functions, including roles in normal cell proliferation and chromatin regulation.
  • Understanding ING protein functions in chromatin signaling is critical for cancer research.
  • Further investigation into ING proteins may reveal new therapeutic targets for cancer.
Keywords:
INGINhibitor of GrowthPHDcancerchromatinhistone mark readeroncoproteinsplant homeodomain

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