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Factors Influencing Drug Absorption: Pharmaceutical Parameters

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...

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Related Experiment Video

Updated: Nov 7, 2025

Twin-Screw Extrusion Process to Produce Renewable Fiberboards

Twin-Screw Extrusion Process to Produce Renewable Fiberboards

Published on: January 27, 2021

Advances in Twin-Screw Granulation Processing.

Uttom Nandi^1,2, Vivek Trivedi³, Steven A Ross^2,4

¹Faculty of Engineering and Science, School of Science, University of Greenwich, Chatham Maritime, Chatham, Kent ME4 4TB, UK.

|April 30, 2021

Summary

This summary is machine-generated.

Twin-screw granulation (TSG) offers flexible and controlled manufacturing for oral dosage forms. This pharmaceutical technology integrates Quality by Design (QbD) and Process Analytical Tools (PAT) for enhanced granule quality.

Keywords:

PAT tools QbD continuous processing granulation mechanisms twin-screw granulation

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Fragmenting Bulk Hydrogels and Processing into Granular Hydrogels for Biomedical Applications

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Published on: May 17, 2022

Area of Science:

Pharmaceutical Technology
Chemical Engineering
Materials Science

Background:

Twin-screw granulation (TSG) is a rapidly evolving pharmaceutical process for oral dosage form development.
TSG technology offers flexibility in equipment design, process variables, and material selection.
It combines benefits of batch and continuous manufacturing with excellent process control.

Purpose of the Study:

To present the fundamental concepts of various twin-screw granulation techniques.
To detail the advantages and disadvantages of different TSG methods.
To discuss instrumentation and the impact of critical processing parameters (CPP) on critical quality attributes (CQA).

Main Methods:

Review of twin-screw granulation techniques and their applications.
Analysis of instrumentation used in TSG processes.
Discussion of the relationship between CPP and CQA in granule formation.

Main Results:

Detailed overview of TSG techniques, including their pros and cons.
Explanation of how critical processing parameters influence granule properties.
Exploration of recent advancements in continuous TSG manufacturing.

Conclusions:

TSG enables high product quality through Quality by Design (QbD) and Process Analytical Tools (PAT).
Understanding CPP-CQA relationships is crucial for optimizing TSG processes.
Continuous manufacturing paradigms in TSG are advancing through modeling and PAT integration.