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S-Nitrosylation in Tumor Microenvironment

Vandana Sharma1, Veani Fernando1, Joshua Letson1

  • 1Department of Cancer Biology, University of Toledo Health Science Campus, 3000 Arlington Ave., Toledo, OH 43614, USA.

International Journal of Molecular Sciences
|April 30, 2021
PubMed

Insights

S-nitrosylation, a modification by nitric oxide (NO), impacts protein function and cellular signaling. This review explores its role in the tumor microenvironment (TME) and potential cancer therapies.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cancer Biology

Background:

  • S-nitrosylation is a reversible post-translational modification of protein thiols by nitric oxide (NO).
  • It modulates protein conformation, activity, stability, and interactions, propagating NO signals.
  • S-nitrosylation influences both tumor suppression and promotion, impacting cancer progression.

Purpose of the Study:

  • To review the effects of S-nitrosylation on cells within the tumor microenvironment (TME).
  • To discuss the context-dependent outcomes of S-nitrosylation in the TME.
  • To explore therapeutic strategies targeting S-nitrosylation in cancer.

Main Methods:

  • Literature review of S-nitrosylation in cancer biology.
  • Analysis of S-nitrosylation's role in tumor microenvironment regulation.
  • Examination of therapeutic interventions modulating S-nitrosylation.

Main Results:

  • S-nitrosylation is a key regulator of the TME.
  • Its effects on TME cells are diverse and context-dependent.
  • Modulating S-nitrosylation shows therapeutic potential in cancer treatment.

Conclusions:

  • S-nitrosylation significantly impacts the TME and cancer pathogenesis.
  • Targeting S-nitrosylation offers promising avenues for cancer therapy.
  • Further research is needed to fully elucidate context-dependent effects for optimized treatment.
Keywords:
ECMNONOSS-nitrosylationcancer therapeuticsmicrobiomemicroenvironmenttumor-associated immune cells

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