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Updated: Nov 7, 2025

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

Published on: November 23, 2015

Microsphere-Based Microfluidic Device for Plasma Separation and Potential Biochemistry Analysis Applications.

Hongyan Xu¹, Zhangying Wu¹, Jinan Deng¹

¹Key Laboratory of Biorheological Science and Technology, Ministry of Education and Bioengineering College, Chongqing University, Chongqing 400030, China.

|April 30, 2021

Summary

This summary is machine-generated.

A novel microfluidic device efficiently separates plasma from blood using microspheres, enabling portable and cost-effective biochemical analysis for clinical diagnostics. Correction factors address evaporation and microsphere effects, validating its use with real patient samples.

Keywords:

concentration detection microchip microspheres stacking plasma separation

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Area of Science:

Biomedical Engineering
Clinical Diagnostics
Microfluidics

Background:

Plasma separation is crucial for blood biochemical analysis in clinical diagnostics.
Existing methods can be complex, expensive, or lack portability.
There is a need for simple, cost-effective, and portable plasma separation platforms.

Purpose of the Study:

To develop and validate a portable microfluidic plasma separation device.
To investigate the impact of microspheres and evaporation on plasma analysis.
To establish correction factors for accurate biochemical analysis.

Main Methods:

A microfluidic device with 18 capillary microchannels was designed.
Microspheres of varying sizes were employed as the separation barrier.
Plasma extraction efficiency, evaporation effects, and microsphere barrier impact were quantified.
Correction factors were developed and applied.
The device's feasibility was tested using clinical blood samples.

Main Results:

The device successfully extracted approximately 3 μL of plasma from a 50 μL blood sample in about 55 minutes.
Evaporation and microsphere barrier effects on plasma biochemical analysis were identified.
Correction factors were successfully applied to compensate for these effects.
The device demonstrated feasibility for clinical plasma biochemical analysis.

Conclusions:

A simple, portable, and cost-effective microfluidic plasma separation platform was developed.
The platform utilizes microspheres as an effective separation barrier.
The developed correction factors enable accurate biochemical analysis from the separated plasma.
This technology holds promise for advancing point-of-care clinical diagnostics.