Genetic Predictors for Sinusoidal Obstruction Syndrome-A Systematic Review.

Area of Science:

• Hematology
• Genetics
• Oncology

Background:

• Sinusoidal obstruction syndrome (SOS) is a severe complication following hematopoietic stem cell transplantation (HSCT) and chemotherapy.
• Existing research on genetic associations with SOS is inconclusive, necessitating a comprehensive review.

Purpose of the Study:

• To systematically review and identify genes, variants, and analytical methods associated with SOS.
• To evaluate the quality and scope of existing genetic association studies for SOS.

Main Methods:

• Systematic literature review of studies investigating genetic markers for SOS.
• Included studies on HSCT and antineoplastic treatment without HSCT.
• Assessed study quality, sample size, and analytical approaches (candidate-gene vs. whole-exome sequencing).

Main Results:

• 27 studies were reviewed (23 post-HSCT, 4 non-HSCT).
• Candidate-gene approaches dominated (26 studies), with whole-exome sequencing in only one.
• GSTA1, MTHFR, GSTM1, and others showed associations with SOS; UGT2B10 and LNPK identified via WES.
• Significant heterogeneity in populations and study designs was observed.

Conclusions:

• Evidence for specific genetic variants predisposing to SOS remains limited and inconsistent.
• Future research requires larger, homogenous cohorts, covariate adjustment, and independent replication.
• Standardized methodologies are crucial for advancing understanding of SOS genetics.