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Updated: Nov 7, 2025

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Published on: February 24, 2023
Autoinflammatory Features in Gouty Arthritis
Paola Galozzi1, Sara Bindoli1, Andrea Doria1
1Rheumatology Unit, Department of Medicine-DIMED, University of Padova, 35128 Padova, Italy.
Abstract:
In the panorama of inflammatory arthritis, gout is the most common and studied disease. It is known that hyperuricemia and monosodium urate (MSU) crystal-induced inflammation provoke crystal deposits in joints. However, since hyperuricemia alone is not sufficient to develop gout, molecular-genetic contributions are necessary to better clinically frame the disease. Herein, we review the autoinflammatory features of gout, from clinical challenges and differential diagnosis, to the autoinflammatory mechanisms, providing also emerging therapeutic options available for targeting the main inflammatory pathways involved in gout pathogenesis. This has important implication as treating the autoinflammatory aspects and not only the dysmetabolic side of gout may provide an effective and safer alternative for patients even in the prevention of possible gouty attacks.
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