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Methods for the detection of adverse drug reactions in hospitalized children: a systematic review

Sheila Feitosa Ramos1,2, Nathália Rodrigues Alvarez3, Thaciana Dos Santos Alcântara1

  • 1Laboratory of Teaching and Research in Social Pharmacy (LEPFS-UFS), Department of Pharmacy, Federal University of Sergipe, São Cristóvão, SE, Brazil.

Expert Opinion on Drug Safety
|April 30, 2021
PubMed

Insights

Detecting adverse drug reactions (ADRs) in hospitalized children is crucial for improving pediatric patient safety. This systematic review highlights the need for better ADR detection methods in this vulnerable population.

Area of Science:

  • Pediatric Pharmacology
  • Drug Safety
  • Clinical Pharmacy

Background:

  • Adverse drug reactions (ADRs) pose a significant global healthcare challenge.
  • Pediatric patients are a vulnerable population at increased risk for ADRs.
  • Current methods for ADR detection in children are insufficient.

Purpose of the Study:

  • To systematically review existing literature on ADR detection in hospitalized pediatric patients.
  • To identify effective strategies for improving ADR identification in children.
  • To emphasize the need for enhanced pediatric drug safety data.

Main Methods:

  • Systematic literature search conducted across major databases (PubMed/Medline, Scopus, LILACS, Web of Science, Embase, Cochrane Library).
  • Study selection adhered to PRISMA statements.
  • Data collection focused on studies published up to April 2020.

Main Results:

  • Limited progress in ADR detection methods specifically for pediatric patients was identified.
  • The review underscores the critical need for increased pediatric drug safety data.
  • Trigger tools correlated with electronic medical records show promise for ADR identification.

Conclusions:

  • Improving childcare necessitates an increase in pediatric drug safety data.
  • Continuous educational programs on ADR detection tools are vital for healthcare professionals.
  • A combined approach, considering the unique aspects of each practice scenario, is recommended for effective ADR assessment in pediatric patients.

Keywords:
Adverse drug reactionschildrenhospitalspediatricspharmacovigilancesystematic review

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