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Updated: Nov 7, 2025

Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
SARS-CoV-2 interacts with platelets and megakaryocytes via ACE2-independent mechanism
Shu Shen1,2, Jingyuan Zhang1, Yaohui Fang1
1State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Hubei Province, Xiaohongshan 44#, Wuchang District, Wuhan City, 430071, People's Republic of China.
Abstract:
Evidence suggests that platelets may directly interact with SARS-CoV-2, raising the concern whether ACE2 receptor plays a role in this interaction. The current study showed that SARS-CoV-2 interacts with both platelets and megakaryocytes despite the limited efficiency. Abundance of the conventional receptor ACE2 and alternative receptors or co-factors for SARS-CoV-2 entry was characterized in platelets from COVID-19 patients and healthy persons as well as human megakaryocytes based on laboratory tests or previously reported RNA-seq data. The results suggest that SARS-CoV-2 interacts with platelets and megakaryocytes via ACE2-independent mechanism and may regulate alternative receptor expression associated with COVID-19 coagulation dysfunction.
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