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Epstein-Barr virus-encoded microRNAs involve in tumorigenesis and development.

Weiming Li1,2, Weihong Yi3, Dazhi Yang3

  • 1Department of Orthopedics, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen Guangdong 518000. liweiming@csu.edu.cn.

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
|April 30, 2021
PubMed
Summary

Epstein-Barr virus (EBV) microRNAs are linked to cancer development. These EBV-encoded microRNAs regulate host genes, influencing tumor apoptosis, proliferation, invasion, and metastasis in various cancers.

Keywords:
Epstein-Barr virus-encoded microRNAsepithelial-mesenchymal transitionlatent infectiontumor

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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
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Area of Science:

  • Oncology
  • Virology
  • Molecular Biology

Background:

  • Epstein-Barr virus (EBV) is a known oncogenic virus implicated in several human malignancies.
  • EBV infection is associated with nasopharyngeal cancer, gastric cancer, and lymphomas.
  • EBV encodes microRNAs that modulate host and viral gene expression.

Purpose of the Study:

  • To elucidate the role of EBV-encoded microRNAs in tumorigenesis.
  • To understand how EBV microRNAs regulate cellular processes critical for cancer development.

Main Methods:

  • Analysis of EBV-encoded microRNA sequences.
  • Investigating the regulatory functions of EBV microRNAs on viral and host genes.
  • Assessing the impact of EBV microRNAs on tumor-associated biological functions.

Main Results:

  • EBV encodes 44 mature microRNAs.
  • These microRNAs regulate both viral and host gene expression.
  • EBV microRNAs are involved in key cancer processes including apoptosis, proliferation, invasion, and metastasis.

Conclusions:

  • EBV-encoded microRNAs play a significant role in the development and progression of EBV-associated tumors.
  • Targeting EBV microRNAs could offer novel therapeutic strategies for virus-driven cancers.