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Association of Polyvascular Disease and Elevated Interleukin-6 With Outcomes in Acute Ischemic Stroke or Transient

Ye Tian1, Jing Jing2,3, Huijuan Wang1

  • 1Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.

Frontiers in Neurology
|April 30, 2021
PubMed

Insights

Polyvascular disease (PolyVD) and elevated interleukin-6 (IL-6) levels independently increase stroke recurrence risk. Combining PolyVD and high IL-6 identifies patients with the highest risk, necessitating targeted interventions.

Area of Science:

  • Cardiovascular Medicine
  • Neurology
  • Biomarkers

Background:

  • Polyvascular disease (PolyVD) and elevated interleukin-6 (IL-6) are known risk factors for poor stroke outcomes.
  • The combined impact of PolyVD and IL-6 on stroke prognosis remains incompletely understood.

Purpose of the Study:

  • To investigate the synergistic effect of PolyVD and elevated IL-6 levels on the risk of recurrent stroke.
  • To assess the combined utility of PolyVD and IL-6 for stroke risk stratification.

Main Methods:

  • Analysis of data from the Third China National Stroke Registry (CNSR-III) including 10,773 patients.
  • PolyVD defined as acute ischemic stroke (AIS) or transient ischemic attack (TIA) with coronary artery disease (CAD) and/or peripheral artery disease (PAD).
  • Patients categorized by PolyVD status and IL-6 levels (≥ 2.64 pg/mL vs. < 2.64 pg/mL); Cox proportional hazard models used for 1-year recurrent stroke risk assessment.

Main Results:

  • The cumulative incidence of recurrent stroke was 9.87% at 1-year follow-up.
  • Elevated IL-6 (HR 1.245) and PolyVD (HR 1.251) were independently associated with increased recurrent stroke risk.
  • The combination of PolyVD and elevated IL-6 demonstrated the highest risk of recurrent stroke (HR 1.290).

Conclusions:

  • Both PolyVD and elevated IL-6 levels are significant predictors of poor outcomes in AIS/TIA patients.
  • The combined assessment of PolyVD and IL-6 enhances stroke risk stratification compared to individual factors.
  • Patients with both PolyVD and elevated IL-6 require heightened clinical attention and intensive management strategies.

Keywords:
interleukin 6ischemic strokepolyvascular diseasestroke recurrencetransient ischemic attack

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