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Paraneoplastic limbic encephalitis due to lung squamous cell carcinoma
Tetsuya So1, Naoki Yamashita1, Hidehiko Shimokawa2
1Department of Thoracic Surgery, Shinkomonji Hospital, Kitakyushu, Fukuoka, Japan.
Journal of Surgical Case Reports
|April 30, 2021
Summary
Paraneoplastic limbic encephalitis (PLE), a rare neurological disorder, can rapidly progress even in early-stage lung cancer. Prompt brain imaging is crucial for diagnosing PLE in cancer patients with neurological symptoms.
Area of Science:
- Neurology
- Oncology
Background:
- Paraneoplastic limbic encephalitis (PLE) is a rare manifestation of paraneoplastic neurological syndromes (PNS).
- This case highlights the association between PLE and lung squamous cell carcinoma.
Observation:
- An 80-year-old woman presented with neurological symptoms.
- Brain MRI showed limbic encephalitis, and chest imaging revealed lung cancer.
- The patient had T1bN0M0 lung squamous cell carcinoma.
Findings:
- The patient died 50 days post-surgery due to rapid encephalitis progression.
- Early-stage lung cancer associated with PLE indicates a poor prognosis.
Implications:
- Clinicians should suspect PLE in cancer patients with rapidly progressing neurological deficits.
- Detailed brain examinations are essential for early diagnosis and management of PLE.
Keywords:
lung squamous cell carcinomaparaneoplastic limbic encephalitis (PLE)paraneoplastic neurological syndrome (PNS)
