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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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Prevention of Vascular Calcification by Magnesium and Selected Polyphenols

Haile Mehansho1, Satya Majeti1, Gabe Tzeghai1

  • 1Summit Innovation Labs, 1776 Mentor Avenue, Cincinnati, OH 45212, USA.

Advances in Preventive Medicine
|April 30, 2021
PubMed

Insights

Magnesium (Mg) combined with quercetin, curcumin, and resveratrol synergistically inhibits arterial vascular calcification (VC). This combination therapy shows greater efficacy than individual components, offering a promising strategy for preventing cardiovascular disease.

Area of Science:

  • Biochemistry
  • Cardiovascular Research
  • Cell Biology

Background:

  • Arterial vascular calcification (VC) involves calcium phosphate deposits in arteries, impeding blood flow and increasing cardiovascular disease risk.
  • VC is a regulated process where vascular smooth muscle cells (VSMCs) transform into bone-like cells, leading to hydroxyapatite deposition.
  • Natural bioactives like quercetin (Q), curcumin (C), resveratrol (R), and magnesium (Mg) have demonstrated potential in inhibiting VC.

Purpose of the Study:

  • To evaluate the in vitro protective effects of magnesium (Mg) combined with polyphenols (Q, C, R) against arterial vascular calcification (VC).
  • To assess the efficacy of individual and combined natural bioactives in preventing calcium deposition in rat vascular smooth muscle cells (rVSMCs).

Main Methods:

  • Rat vascular smooth muscle cells (rVSMCs) were cultured in a high phosphate (HP) medium to induce calcification.
  • The effects of Mg, and a combination of Q, C, and R, both separately and together, on calcium deposition were measured.
  • Calculated additive inhibition was compared with the observed inhibition by the combined treatment.

Main Results:

  • Magnesium (Mg) alone decreased HP-induced calcium deposition by 37.55%.
  • The combination of quercetin (Q), curcumin (C), and resveratrol (R) alone decreased calcium deposition by 42.78%.
  • The combined administration of Mg with Q, C, and R demonstrated a significant synergistic effect, inhibiting calcium deposition by 92.88%, exceeding the additive effect of 80.33%.

Conclusions:

  • The combination of Mg with selected polyphenols (Q, C, R) exhibits superior efficacy in inhibiting vascular calcification compared to individual treatments.
  • This synergistic effect suggests a potent therapeutic strategy for mitigating VC, a critical risk factor for cardiovascular disease.
  • Regular intake of these natural bioactives may offer protective benefits against the development of heart diseases.

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