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Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody
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T-cell receptor mimic (TCRm) antibody therapeutics against intracellular proteins

Yixiang Xu1, Georgina To'a Salazar1, Ningyan Zhang1

  • 1Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

Antibody Therapeutics
|April 30, 2021
PubMed

T-cell receptor mimic (TCRm) antibodies combine the capacity of a T cell to target intracellular antigens with other capacities unique to antibodies. Neoantigens are abnormal proteins that arise as a consequence of somatic mutations. Technological advances promote the development of neoantigen-targeting therapies including TCRm antibody therapies. This review summarizes key characteristics of TCRm antibodies, in particular those targeting neoantigens, and further introduces discussion of obstacles that must be overcome to advance TCRm therapeutics.

Keywords:
CAR-T cell therapyTCR receptor mimic antibodybispecific antibody T cell engagercancer testis antigen (CTA)neoantigen

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