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Pink1-/- rats are a useful tool to study early Parkinson disease

Cynthia A Kelm-Nelson1, Sarah A Lechner1, Samantha E Lettenberger1

  • 1Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin Madison, Madison, WI 53706, USA.

Brain Communications
|April 30, 2021
PubMed
Abstract

No abstract available in PubMed .

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Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...