Related Experiment Video
Updated: Nov 7, 2025
Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility
Published on: April 5, 2024
A systematic review of toll-like receptors in endometriosis
Bruna Cestari de Azevedo1, Fernanda Mansur2, Sérgio Podgaec2
1Hospital Israelita Albert Einstein, Instituto Israelita de Ensino e Pesquisa Albert Einstein, Avenida Albert Einstein, 627, Morumbi, São Paulo, CEP 05652-900, Brazil. bruna@cestari.eu.
Introduction:
The pathogen-associated molecular patterns and the danger-associated molecular patterns are possibly responsible for the activation of the inflammatory process in endometriosis through the activation of toll-like receptors (TLRs).
Objective:
The aim of this systematic review was to critically analyze the findings of published articles on TLRs in endometriosis.
Methods:
The keywords used were "endometriosis" and "toll-like" and the search was performed in Pubmed, Scielo and Lilacs databases. This study followed the PRISMA guidelines and the risk of bias of articles was conducted by Newcastle-Ottawa scale (NOS).
Results:
Overall, the studies analyzed in this review point toward an increased expression of TLRs two, four and nine in women with endometriosis. Among all TLRs, TLR4 was the most cited receptor.
Conclusion:
Despite the evidence demonstrating elevated TLR levels in endometriosis, the relationship with the disease is still unclear and needs to be clarified in further studies about innate immune response.
More Related Videos
07:20Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity
Published on: December 21, 2012
08:02Mouse Model of Surgically-induced Endometriosis by Auto-transplantation of Uterine Tissue
Published on: January 6, 2012