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Updated: Nov 7, 2025

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis
Published on: March 25, 2016
Analysis of T-Cells in Inflamed Nonlymphoid Tissues
Laura Bauer1,2, Andreas Hutloff3,4
1Chronic Immune Reactions, German Rheumatism Research Center, A Leibniz Institute, Berlin, Germany.
Abstract:
Under chronic inflammatory conditions, T and B cells are frequently found in nonlymphoid tissues. We recently identified a follicular helper-like T cell population in inflamed lung tissue, which drives the local differentiation of antigen-specific B cells into germinal center-like cells and plasma blasts. Here, we describe a lung inflammation mouse model, which is ideally suited to analyze antigen-specific T and B cells in secondary lymphoid organs and inflamed nonlymphoid tissue in parallel.
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