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Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
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Circ0021205 aggravates the progression of non-small cell lung cancer by targeting miRNA-16-5p/VEGFA

Y Yang1, X-J Huang

  • 1Department of Respiratory Medicine, 2nd Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

European Review for Medical and Pharmacological Sciences
|April 30, 2021
PubMed

Insights

This study on non-small cell lung cancer (NSCLC) has been retracted due to inaccuracies. The article investigated Circ0021205, microRNA-16-5p, and VEGFA in NSCLC progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Non-small cell lung cancer (NSCLC) is a leading cause of cancer mortality.
  • Understanding the molecular mechanisms driving NSCLC progression is crucial for developing effective therapies.
  • Circular RNAs (circRNAs) have emerged as significant regulators in various cancers, including NSCLC.

Purpose of the Study:

  • To investigate the role of Circ0021205 in the progression of non-small cell lung cancer.
  • To elucidate the targeting relationship between Circ0021205, microRNA-16-5p (miRNA-16-5p), and Vascular Endothelial Growth Factor A (VEGFA).

Main Methods:

  • The study aimed to analyze the expression and function of Circ0021205 in NSCLC.
  • Investigate the interaction between Circ0021205, miRNA-16-5p, and VEGFA using molecular biology techniques.

Main Results:

  • The original publication reported that Circ0021205 aggravates NSCLC progression.
  • Findings suggested a targeting mechanism involving Circ0021205 and miRNA-16-5p, affecting VEGFA expression.

Conclusions:

  • The article "Circ0021205 aggravates the progression of non-small cell lung cancer by targeting miRNA-16-5p/VEGFA" has been withdrawn due to inaccuracies.
  • The publisher apologizes for any inconvenience caused by this retraction.

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