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Related Experiment Video

Updated: Nov 7, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

An update on Sars-CoV-2: a review.

Dur E Nishwa¹, Hafiza Arooba Riaz¹, Ameer Fatima²

¹Department of Life Sciences, School of Sciences, University of Management and Technology, Lahore, Pakistan.

Theoretical Biology Forum

|April 30, 2021

Summary

The novel coronavirus, SARS-CoV-2, causes COVID-19, a pandemic with diverse symptoms and no current treatment. This review updates genomic characterization, transmission, diagnosis, and clinical aspects of SARS-CoV-2.

Keywords:

Covid 19, Genome Pathogenesis Sars-CoV-2

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Area of Science:

Virology
Public Health
Infectious Diseases

Background:

The emergence of SARS-CoV-2 as a global health challenge, declared a pandemic in March 2020.
Rapid global spread, infecting millions within months.
Wide spectrum of clinical manifestations, from mild to severe respiratory and multi-organ complications.

Purpose of the Study:

To provide a comprehensive review of the latest updates on SARS-CoV-2.
To consolidate information on genomic characterization, transmission, diagnosis, and clinical presentation.
To highlight existing knowledge gaps and the need for further research.

Main Methods:

Review of current scientific literature and research on SARS-CoV-2.
Synthesis of data on viral genomics, transmission dynamics, diagnostic methods, and clinical outcomes.
Analysis of the current therapeutic landscape and ongoing research efforts.

Main Results:

SARS-CoV-2 is highly contagious, spreading via respiratory droplets.
Clinical symptoms vary widely, with severe cases leading to pneumonia, ARDS, sepsis, and organ failure.
No specific treatment is currently available, emphasizing the need for ongoing research.

Conclusions:

The review consolidates critical information on SARS-CoV-2, aiding researchers and clinicians.
Understanding genomic variations, transmission patterns, and clinical features is crucial for effective management.
Further research is essential to develop effective treatments and control strategies against SARS-CoV-2.