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FTO Obesity Variant-Exercise Interaction on Changes in Body Weight and BMI: The Taiwan Biobank Study
Yuta Hiraike1,2, Chao-Tung Yang3,4,5, Wei-Ju Liu6
1Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
The Journal of Clinical Endocrinology and Metabolism
|April 30, 2021
Summary
Regular exercise significantly impacts weight changes, especially for those with the FTO obesity gene variant. Exercise benefits are amplified in individuals genetically predisposed to obesity, aiding weight management.
Area of Science:
- Genetics and Obesity Research
- Exercise Physiology and Weight Management
Background:
- Gene-exercise interactions are established for cross-sectional Body Mass Index (BMI).
- Interaction effects on longitudinal changes in body weight and BMI remain controversial.
Purpose of the Study:
- To investigate the interaction between the FTO obesity variant (rs1421085) and regular exercise on changes in body weight and BMI.
- To clarify the role of genetic predisposition in exercise-induced weight management.
Main Methods:
- Study included 20,906 Taiwan Biobank participants aged 30-70 years.
- Baseline and follow-up assessments (average 3.7 years) measured body weight and BMI.
- Analysis focused on the FTO variant rs1421085 and exercise habits (none, ≤20 METs/week, >20 METs/week).
Main Results:
- Individuals with the FTO risk allele gained more weight/BMI without exercise.
- Conversely, those with the risk allele gained less weight/BMI with regular exercise (P = .030 for weight, P = .034 for BMI).
- Exercise demonstrated a greater weight-maintaining effect in individuals with the FTO risk allele.
Conclusions:
- A significant interaction exists between the FTO variant rs1421085 and regular exercise concerning body weight and BMI changes.
- The beneficial impact of exercise on weight management is more pronounced in individuals genetically susceptible to obesity.
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