Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mass and Weight01:19

Mass and Weight

14.1K
Mass and weight are often used interchangeably in everyday conversation. For example,  medical records often show our weight in kilograms, but never in the correct units of newtons. In physics, however, there is an important distinction. Weight is the pull of the Earth on an object. It depends on the distance from the center of the Earth. Weight dramatically varies if we leave the Earth's surface, unlike mass, which does not vary with location. On the Moon, for example, the...
14.1K
Center of Mass: Introduction01:03

Center of Mass: Introduction

17.8K
Any object that obeys Newton's second law of motion is made up of a large number of infinitesimally small particles. Objects in motion can be as simple as atoms or as complex as gymnasts performing in the Olympics. The motion of such objects is described about a point called the center of mass of the object. The center of mass of an object is a point that acts as if the whole mass is concentrated at that point. The center of mass of an object with a large number of infinitesimally small...
17.8K
Basic Concept01:28

Basic Concept

3.3K
Engineering mechanics is a branch of engineering that studies motion and the forces acting on objects. It is a fundamental subject and forms the basis of many other engineering disciplines. Length, time, mass, and force are some basic concepts in engineering mechanics.
Length, which measures the distance traveled by an object, is a fundamental concept in engineering mechanics. We use coordinates relative to a reference point to describe the distance. Length not only helps to describe the...
3.3K
The Scope of Physics01:17

The Scope of Physics

47.3K
Physics is concerned with the interactions of energy, matter, space, and time, in order to discover the underlying mechanisms that underpin all phenomena. The word "physics" comes from the Greek word "phúsis", which means nature. Physics seeks to comprehend the natural world around us at its most fundamental level. It emphasizes the use of quantitative laws to do this, which could be valuable in other fields that want to push the performance boundaries of present...
47.3K
Significance of Center of Mass01:12

Significance of Center of Mass

7.2K
The center of mass of an object is defined as the mass-weighted average position of all the particles that comprise the object. The significance of the center of mass of an object can be seen by looking at its dynamics. The time derivative of the center of mass gives its velocity, assuming that the object's mass remains constant over time. Furthermore, the total linear momentum of an object can be seen as the linear momentum of a single particle of the object's total mass moving with...
7.2K
Dimensional Analysis01:23

Dimensional Analysis

1.6K
Dimensional analysis is a powerful tool that is used in physics and engineering to understand and predict the behavior of physical systems. The basic idea behind dimensional analysis is to express physical quantities in terms of fundamental dimensions such as the mass, length, and time. Derived dimensions like the velocity, acceleration, and force are derived from the combinations of these fundamental dimensions.
Dimensional analysis allows us to analyze and compare physical quantities on a...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The action of marimastat, a metalloprotease inhibitor, on the coagulant, hemorrhagic, and neuromuscular activities of Lachesis muta (South American bushmaster) venom.

Toxicon : official journal of the International Society on Toxinology·2026
Same author

New Insights into the Bioenergetic and Immunomodulatory Properties of Phospholipases A<sub>2</sub> from <i>Bothrops diporus</i> Venom.

Toxins·2026
Same author

Venomics across the <i>Bothrops neuwiedi</i> Species Complex Revealed a P-III Snake Venom Metalloproteases/K49-PLA<sub>2</sub> Dichotomy and a Remarkable Paraspecific Neutralization of the Brazilian Pentabothropic Antivenom.

Journal of proteome research·2026
Same author

Differential coagulotoxic activity of Lonomia obliqua venom on human and chicken plasmas.

Toxicon : official journal of the International Society on Toxinology·2025
Same author

Interspecific and intraspecific variability in venom composition of Naja naja and Naja kaouthia (Reptilia: Elapidae) populations from different habitats in Bangladesh.

Journal of proteomics·2025
Same author

Rational design of antibodies with pH-dependent antigen-binding properties using structural insights from broadly neutralizing antibodies against α-neurotoxins.

mAbs·2025
Same journal

TDP-43 proteinopathy as a biomarker and therapeutic target in amyotrophic lateral sclerosis.

Biochemical Society transactions·2026
Same journal

Advancing the monitoring of organelle contact sites in vitro and in vivo.

Biochemical Society transactions·2026
Same journal

Mechanisms influencing transient cytoplasmic protein targeting to intracellular lipid droplets.

Biochemical Society transactions·2026
Same journal

Replication associated nuclear DNA mismatch repair across kingdoms.

Biochemical Society transactions·2026
Same journal

Phosphatases of regenerating liver downregulate PTEN to promote tumorigenesis.

Biochemical Society transactions·2026
Same journal

Implications of Rho GTPase signaling in cancer immunotherapy.

Biochemical Society transactions·2026
See all related articles

Related Experiment Video

Updated: Nov 7, 2025

An Analog Macroscopic Technique for Studying Molecular Hydrodynamic Processes in Dense Gases and Liquids
11:03

An Analog Macroscopic Technique for Studying Molecular Hydrodynamic Processes in Dense Gases and Liquids

Published on: December 4, 2017

8.7K

What's in a mass?

Juan J Calvete1, Libia Sanz1, Diana Mora-Obando1

  • 1Evolutionary and Translational Venomics Laboratory, Instituto de Biomedicina de Valencia, CSIC, Valencia, Spain.

Biochemical Society Transactions
|April 30, 2021
PubMed
Summary
This summary is machine-generated.

Determining a protein's unique molecular mass, including its isotopic distribution, aids in differentiating it within an organism's proteome. This mass profiling of snake venom phospholipase A2 (PLA2) reveals species dispersal routes and phylogeographic patterns.

Keywords:
biological mass spectrometrysnake venomvenomics

More Related Videos

Setting Limits on Supersymmetry Using Simplified Models
07:46

Setting Limits on Supersymmetry Using Simplified Models

Published on: November 15, 2013

8.7K
Generation and Coherent Control of Pulsed Quantum Frequency Combs
06:42

Generation and Coherent Control of Pulsed Quantum Frequency Combs

Published on: June 8, 2018

9.3K

Related Experiment Videos

Last Updated: Nov 7, 2025

An Analog Macroscopic Technique for Studying Molecular Hydrodynamic Processes in Dense Gases and Liquids
11:03

An Analog Macroscopic Technique for Studying Molecular Hydrodynamic Processes in Dense Gases and Liquids

Published on: December 4, 2017

8.7K
Setting Limits on Supersymmetry Using Simplified Models
07:46

Setting Limits on Supersymmetry Using Simplified Models

Published on: November 15, 2013

8.7K
Generation and Coherent Control of Pulsed Quantum Frequency Combs
06:42

Generation and Coherent Control of Pulsed Quantum Frequency Combs

Published on: June 8, 2018

9.3K

Area of Science:

  • Proteomics
  • Evolutionary Biology
  • Biochemistry

Background:

  • The amino acid sequence is a primary characteristic of proteins.
  • Understanding protein molecular mass is crucial for biological research.
  • Snake venomics research benefits from detailed molecular property analysis.

Purpose of the Study:

  • To explore the significance of biological mass in protein identification.
  • To highlight the value of molecular mass determination in evolutionary and translational snake venomics.
  • To demonstrate how mass profiling can elucidate phylogeographic patterns.

Main Methods:

  • Analysis of protein molecular mass and isotopic distribution.
  • Mass profiling of snake venom phospholipase A2 (PLA2).
  • Comparative analysis across conspecific populations.

Main Results:

  • Isotopic distribution of molecular mass uniquely identifies proteins within a proteome.
  • Mass profiling of snake venom PLA2 provided insights into species dispersal.
  • Phylogeographic patterns were elucidated through mass profiling data.

Conclusions:

  • Molecular mass determination is a powerful tool for protein differentiation.
  • Snake venomics can be advanced by utilizing mass spectrometry-based approaches.
  • Protein mass profiling aids in understanding evolutionary processes and species distribution.