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Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Updated: Nov 7, 2025

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Alternative indications for corneal crosslinking.

Laurens Van Tigchelt1, Jan Van Eijgen, Heleen Delbeke

  • 1Department of Ophthalmology, University Hospitals Leuven, Leuven, Belgium (Van Tigchelt, Van Eijgen, Delbeke), the KU Leuven, Biomedical Sciences Group, Department of Neurosciences, Research group Ophthalmology, Leuven, Belgium (Van Eijgen, Delbeke), the VITO (Flemish Institute for Technological Research), Health Unit, Mol, Belgium (Van Eijgen).

Journal of Cataract and Refractive Surgery
|April 30, 2021
PubMed
Summary
This summary is machine-generated.

Corneal crosslinking (CXL) is effective for post-LASIK ectasia and shows promise for bacterial keratitis. Further research is needed for conditions like pellucid marginal degeneration, as current evidence is limited.

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Area of Science:

  • Ophthalmology
  • Corneal Surgery
  • Biomaterials Science

Background:

  • Corneal crosslinking (CXL) is the standard treatment for progressive keratoconus.
  • Investigating alternative indications for CXL is crucial for expanding its therapeutic applications.

Purpose of the Study:

  • To systematically review alternative indications for corneal crosslinking (CXL) beyond keratoconus.
  • To assess the efficacy and evidence base for CXL in various corneal conditions.

Main Methods:

  • Systematic review of 143 papers.
  • Included studies evaluated CXL for infectious keratitis, bullous keratopathy, pellucid marginal degeneration, and post-LASIK ectasia.
  • Assessed CXL as a standalone or adjunctive therapy for visual improvement.

Main Results:

  • Post-LASIK ectasia is a confirmed indication for CXL.
  • Limited research exists for pellucid marginal degeneration, with no randomized trials.
  • CXL shows potential for refractory bacterial keratitis and combined refractive surgery.
  • Benefits in bullous keratopathy appear transient.

Conclusions:

  • Corneal crosslinking has established efficacy for post-LASIK ectasia and potential for infectious keratitis.
  • Further high-quality research is warranted for conditions like pellucid marginal degeneration.
  • CXL may offer novel therapeutic avenues for specific corneal pathologies and refractive error correction.