Related Experiment Video
Updated: Feb 14, 2026
07:02
In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
Published on: August 23, 2019
7.8K
Nutritional modulation of tumor growth
1University of Washington, Seattle 98105.
The Journal of Surgical Research
|July 1, 1988
Summary
Nutritional repletion after protein deficiency impacts tumor and host tissue proliferation. Tumor DNA synthesis resumes faster than liver tissue following refeeding, indicating a nutrient-specific response.
Area of Science:
- Oncology
- Nutritional Science
- Biochemistry
Background:
- Tumor growth is influenced by host nutritional status.
- Understanding nutrient-specific effects on cancer proliferation is crucial for therapeutic strategies.
Purpose of the Study:
- To investigate the relationship between tumor and host tissue proliferation during protein-calorie deficiency and nutritional repletion.
- To compare the effects of a protein-free diet versus starvation on tumor DNA synthesis.
Main Methods:
- C3H female mice with MA16/C tumors were subjected to a protein-free diet (PFD) for 5 days, followed by nutritional repletion.
- Tumor and host tissue DNA synthesis was measured at various time points post-refeeding.
- Compared PFD effects with previous starvation studies.
Main Results:
- Protein-free diet decreased DNA synthesis in both tumor and host tissues.
- Tumor DNA synthesis resumed earlier than liver DNA synthesis after refeeding.
- Isocaloric PFD caused less reduction in tumor DNA synthesis and earlier resumption compared to starvation.
Conclusions:
- Nutritional deprivation and refeeding elicit a nutrient-specific response in tumor and host tissues.
- Tumor proliferation is sensitive to protein availability, with faster recovery than host liver tissue.
Related Concept Videos
01:28Microbial Nutrition
1.5K
Organisms exhibit remarkable metabolic diversity, categorized based on how they acquire energy and carbon. These strategies enable survival in various ecological niches and are essential for maintaining energy flow and nutrient cycling within ecosystems.Energy and Carbon SourcesOrganisms are classified as phototrophs or chemotrophs based on energy acquisition. Phototrophs use light as their energy source, while chemotrophs rely on oxidizing chemical compounds. Further differentiation arises...
1.5K
01:26Enteral Nutrition I: Orogastric and Nasogastric Feeding
1.6K
Enteral nutrition delivers nutrients directly to the stomach or small intestine through a tube. This method is appropriate for patients who cannot eat but still have a functioning digestive system. It is also beneficial for individuals with swallowing difficulties, anorexia, malabsorption, or those who have undergone gastrointestinal (GI) surgery.
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
1.6K
02:11The Roles of Bacteria and Fungi in Plant Nutrition
47.5K
Plants have the impressive ability to create their own food through photosynthesis. However, plants often require assistance from organisms in the soil to acquire the nutrients they need to function correctly. Both bacteria and fungi have evolved symbiotic relationships with plants that help the species to thrive in a wide variety of environments.
47.5K
01:27Parentral Nutrition: Centeral and Peripheral Parental Nutrition
1.0K
Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
1.0K
02:35Key Elements for Plant Nutrition
24.4K
Like all living organisms, plants require organic and inorganic nutrients to survive, reproduce, grow and maintain homeostasis. To identify nutrients that are essential for plant functioning, researchers have leveraged a technique called hydroponics. In hydroponic culture systems, plants are grown—without soil—in water-based solutions containing nutrients. At least 17 nutrients have been identified as essential elements required by plants. Plants acquire these elements from the...
24.4K
00:57Population Growth
28.7K
Population size is dynamic, increasing with birth rates and immigration, and decreasing with death rates and emigration. In ideal conditions with unlimited resources, populations can increase exponentially, which plots as a J-shaped growth rate curve of population size against time. This type of curve is characteristic of newly-introduced invasive species, or populations that have suffered catastrophic declines and are rebounding.
28.7K