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BloodPAC Data Commons for Liquid Biopsy Data.

Robert L Grossman1,2, Jonathan R Dry3, Sean E Hanlon4

  • 1Center for Translational Data Science, University of Chicago, Chicago, IL.

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|April 30, 2021
PubMed
Summary
This summary is machine-generated.

The Blood Profiling Atlas in Cancer (BloodPAC) Data Commons provides a central platform for liquid biopsy research. It supports the scientific community with valuable data and tools for advancing cancer diagnostics.

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Area of Science:

  • Oncology
  • Bioinformatics
  • Genomics

Background:

  • The Blood Profiling Atlas in Cancer (BloodPAC) Consortium developed the BloodPAC Data Commons (BPDC) to support the liquid biopsy research community.
  • Liquid biopsy assays are crucial for cancer detection and monitoring, requiring robust data infrastructure.

Purpose of the Study:

  • To establish an interoperable data commons for liquid biopsy research.
  • To serve as a recognized source of scientific evidence for liquid biopsy assays.
  • To support industry, academia, and regulatory stakeholders in liquid biopsy research.

Main Methods:

  • The BPDC is built on the open-source Gen3 data commons platform.
  • Key components like portals, a workspace hub, and an API were generated from the BloodPAC Data Model.
  • The platform ensures interoperability with other data commons, such as the National Cancer Institute's Cancer Research Data Commons.

Main Results:

  • The BPDC currently manages data from 57 studies, encompassing over 4,100 cases and 5,700 aliquots.
  • It hosts more than 31,000 files as of December 2020.
  • Applications have been developed utilizing the BPDC's API.

Conclusions:

  • The BPDC has served as the primary data management platform for BloodPAC for four years.
  • It facilitates data sharing and provides collaborative workspaces for working groups.
  • The BPDC is a vital resource for advancing liquid biopsy research and its applications in cancer care.