Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

190
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
190
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

90
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
90

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Factors Associated With Poor Outcomes For Female Patients Undergoing Total Shoulder Arthroplasty.

Journal of shoulder and elbow surgery·2026
Same author

Microbial next generation DNA sequencing of aspirated synovial fluid shows concordance with ICM criteria biomarkers for diagnosing periprosthetic joint infection in hip and knee arthroplasty.

Frontiers in microbiology·2026
Same author

Penile prosthetic infections: what can be learned from orthopedics?

The journal of sexual medicine·2026
Same author

Standard vs. the alternative centerline technique for baseplate fixation in reverse shoulder arthroplasty: a comparison of anterior shoulder pain.

Journal of shoulder and elbow surgery·2026
Same author

Anti-Inflammatory Treatment and Active Physical Therapy Have Differing Effects on Functional, Mechanical, and Histological Properties in a Rat Model of Post-Traumatic Elbow Contracture.

Journal of biomechanical engineering·2026
Same author

2025 ICM: Epidemiology, Mortality, Registries, Public Reporting, Specialized Treatment Centers, and Physical and Psychological Impact.

The Journal of arthroplasty·2025

Related Experiment Video

Updated: Nov 7, 2025

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction
10:35

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction

Published on: December 3, 2017

11.3K

Is D-dimer a Reliable Serum Marker for Shoulder Periprosthetic Joint Infection?

Benjamin Zmistowski1, Michael Chang1, Alisina Shahi2

  • 1Department of Orthopaedic Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.

Clinical Orthopaedics and Related Research
|April 30, 2021
PubMed
Summary

Serum D-dimer is elevated in patients with periprosthetic shoulder infections, but it has limited diagnostic value. Combining D-dimer with ESR and CRP improves specificity but lowers sensitivity for diagnosing these infections.

More Related Videos

Measuring 3D In-vivo Shoulder Kinematics using Biplanar Videoradiography
06:09

Measuring 3D In-vivo Shoulder Kinematics using Biplanar Videoradiography

Published on: March 12, 2021

3.4K
A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

17.6K

Related Experiment Videos

Last Updated: Nov 7, 2025

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction
10:35

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction

Published on: December 3, 2017

11.3K
Measuring 3D In-vivo Shoulder Kinematics using Biplanar Videoradiography
06:09

Measuring 3D In-vivo Shoulder Kinematics using Biplanar Videoradiography

Published on: March 12, 2021

3.4K
A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

17.6K

Area of Science:

  • Orthopedic surgery
  • Infectious disease diagnostics
  • Biomarker research

Background:

  • Diagnosing periprosthetic shoulder infection remains challenging.
  • Serum D-dimer is a potential screening tool for periprosthetic joint infections, but its utility in shoulder infections is unevaluated.

Purpose of the Study:

  • To determine if D-dimer is elevated in periprosthetic shoulder infections.
  • To assess the diagnostic accuracy of D-dimer for these infections.
  • To evaluate the diagnostic accuracy of serum tests (ESR, CRP, D-dimer) individually and in combination.

Main Methods:

  • Prospective evaluation of 94 patients undergoing revision total shoulder arthroplasty.
  • Preoperative serum testing for D-dimer, ESR, and CRP.
  • Classification of infection status based on International Consensus Meeting (ICM) definitions.
  • Receiver operating characteristic (ROC) curve analysis for diagnostic accuracy.

Main Results:

  • D-dimer levels were significantly higher in definite/probable infections compared to possible/unlikely infections (p=0.01).
  • D-dimer showed weak diagnostic value (Area Under Curve = 0.71).
  • A D-dimer cutoff of 598 ng/mL yielded 61% sensitivity and 74% specificity.
  • Combining ESR, CRP, and D-dimer increased specificity (88%) but decreased sensitivity (28%) for infection detection.

Conclusions:

  • D-dimer is elevated in periprosthetic shoulder infections but has limited diagnostic utility.
  • Similar to other serum markers, D-dimer alone is insufficient for reliable diagnosis.
  • Further research is needed to elucidate the association between D-dimer and active infection.