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Updated: Nov 7, 2025

Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules

Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules

Published on: June 1, 2011

Woven Electroanalytical Biosensor for Nucleic Acid Amplification Tests.

Shirin Khaliliazar¹, Ingrid Öberg Månsson¹, Andrew Piper¹

¹Department of Fibre and Polymer Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Tekninkringen 56-58, Stockholm, SE-100 44, Sweden.

Advanced Healthcare Materials

|April 30, 2021

Summary

This summary is machine-generated.

This study presents a novel woven biosensor for nucleic acid amplification testing (NAATs). The textile-based device uses electroanalysis for sensitive detection of bacterial DNA, paving the way for point-of-care diagnostics.

Keywords:

electrochemical biosensors nucleic acid amplification tests (NAATs)recombinase polymerase amplification (RPA)self-assembled monolayers (SAMs)textile microfluidics

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Bacterial Detection & Identification Using Electrochemical Sensors

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Published on: April 23, 2013

Area of Science:

Biomedical Engineering
Analytical Chemistry
Materials Science

Background:

Fiber-based biosensors offer a novel approach to diagnostic devices.
Current textile biosensors often rely on colorimetric detection methods.
Integrating microfluidics and electroanalysis in textiles presents an underexplored area.

Purpose of the Study:

To develop and characterize a woven biosensor for nucleic acid amplification testing (NAATs).
To evaluate fiber-based electrodes for self-assembled monolayer (SAM) formation and electrochemical performance in textiles.
To demonstrate the sensor's capability for detecting specific genomic DNA.

Main Methods:

Fabrication of a woven electrochemical DNA (E-DNA) sensor using gold microwires and thiol-SAMs.
Systematic characterization of pure gold microwires and gold-coated polyester threads as fiber-based electrodes.
Utilizing recombinase polymerase amplification (RPA) for isothermal DNA amplification.
Electroanalytical readout for specific DNA detection.

Main Results:

Successful SAM formation and electrochemical performance were observed on both types of fiber electrodes.
The woven E-DNA sensor specifically detected unpurified genomic DNA of Staphylococcus epidermidis.
Detection limit achieved was as low as 10 copies/µL of amplified DNA.

Conclusions:

Textile-based biosensors can be effectively integrated with microfluidics and electroanalysis.
The developed sensor demonstrates potential for sensitive and specific NAATs.
This technology holds promise for automated, sample-to-answer point-of-care diagnostic devices.