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The imitation game: How glioblastoma outmaneuvers immune attack
Ilon Liu1, Olivia A Hack1, Mariella G Filbin1
1Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA, 02215, USA.
Cell
|April 30, 2021
Abstract:
Immune evasion and resistance to immunotherapy mark major roadblocks in treating glioblastoma, the deadliest form of brain cancer. In this issue of Cell, Gangoso et al. demonstrate that the immune microenvironment drives glioblastoma cells to hijack myeloid-characteristic transcriptional and epigenetic circuits as a mode of immune evasion.

