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Targeting the gasdermin D as a strategy for ischemic stroke therapy
Jiabing Wang1, Jiali Yao2, Yugang Liu2
1Municipal Hospital Affiliated to Medical School of Taizhou University, Taizhou 318000, China.
Biochemical Pharmacology
|April 30, 2021
Summary
Gasdermin D (GSDMD) drives pyroptosis, a key inflammatory cell death in stroke. Targeting GSDMD offers a promising therapeutic strategy for ischemic stroke treatment.
Area of Science:
- Neuroscience
- Immunology
- Pathology
Background:
- Stroke is a leading cause of global mortality and disability, associated with significant neuropathological consequences.
- Neuroinflammation, including pyroptosis, plays a critical role in the pathophysiology of ischemic stroke and reperfusion injury.
- Gasdermin D (GSDMD) is identified as the central executor of pyroptosis, mediating inflammatory responses.
Purpose of the Study:
- To review and highlight the role of GSDMD-regulated pyroptosis in ischemic stroke.
- To explore the biological characteristics of GSDMD as a potential therapeutic target.
Main Methods:
- Literature review summarizing existing research on GSDMD, pyroptosis, and ischemic stroke.
- Analysis of the molecular mechanisms of GSDMD in inflammasome activation and pyroptosis execution.
Main Results:
- GSDMD cleavage by caspases initiates pyroptosis, leading to pore formation and cytokine release.
- GSDMD-mediated pyroptosis contributes significantly to neuronal damage and inflammatory cascades in stroke.
- GSDMD's role in initiating inflammatory cell death makes it a viable therapeutic target.
Conclusions:
- GSDMD-regulated pyroptosis is a crucial factor in ischemic stroke pathology.
- Understanding GSDMD's function provides a basis for developing novel therapeutic interventions for stroke.
