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Updated: Nov 7, 2025

Assays for the Degradation of Misfolded Proteins in Cells
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Quality control of mislocalized and orphan proteins

Ka-Yiu Edwin Kong1, João P L Coelho2, Matthias J Feige2

  • 1Institute of Molecular Biology (IMB), Mainz, Germany.

Experimental Cell Research
|April 30, 2021
PubMed
Summary

Cellular proteome homeostasis is vital but challenged by protein errors. This review covers quality control for mislocalized and orphan proteins, linking their accumulation to aging and disease.

Keywords:
AgeingOrphan proteinsProtein mislocalizationProtein quality controlProteostasisSelective protein degradationUbiquitin-proteasome system

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