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Related Experiment Video

Updated: Nov 7, 2025

A Microcontroller Operated Device for the Generation of Liquid Extracts from Conventional Cigarette Smoke and Electronic Cigarette Aerosol
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E-Cigarette-Associated Endothelial Damage: A Potential Mechanism for Erectile Dysfunction.

Joshua Pincus1, Victor Sandoval2, Brian Dick1

  • 1Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA.

Sexual Medicine Reviews
|May 1, 2021
PubMed
Summary
This summary is machine-generated.

Electronic cigarette use may contribute to erectile dysfunction (ED) by causing endothelial damage. Further clinical trials are needed to confirm this link and explore the underlying mechanisms of vaping-induced ED.

Keywords:
E-CigsElectronic CigarettesEndothelial DamageErectile FunctionVaping

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Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System
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Area of Science:

  • Cardiovascular Science
  • Urology
  • Public Health

Background:

  • Electronic cigarettes (e-cigs) are increasingly popular, often perceived as less harmful than traditional tobacco.
  • Emerging evidence suggests e-cig use may induce endothelial damage, a key factor in vascular health.
  • The impact of e-cigs on erectile function remains understudied despite known links between smoking and erectile dysfunction (ED).

Purpose of the Study:

  • To review existing literature on e-cig use and endothelial dysfunction.
  • To explore endothelial dysfunction as a potential pathway to ED.
  • To determine the current evidence base supporting e-cigs as a cause of ED.

Main Methods:

  • A comprehensive literature review was conducted across major scientific databases (PubMed, MEDLINE, Cochrane Library, Web of Science, Google Scholar).
  • Publications focused on e-cig consumption, vascular damage, endothelial damage, and ED were identified and analyzed.
  • Over 40 publications, including clinical trials and basic science studies, were included in the review.

Main Results:

  • Current literature indicates e-cig use promotes oxidative stress, generating reactive oxygen species and hydroxyl radicals, which leads to endothelial damage.
  • Endothelial dysfunction is recognized as a potential mechanism underlying ED.
  • A significant lack of studies specifically evaluating the direct relationship between e-cig use and ED was identified.

Conclusions:

  • E-cigarette use presents a potential risk factor for developing ED in men.
  • Further research, particularly well-designed clinical trials, is essential to establish a definitive causal link between e-cig use and ED.
  • Investigating e-cig-induced endothelial dysfunction warrants further exploration as a primary mechanism for ED.