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Related Experiment Video

Updated: Nov 7, 2025

Protocols for Robust Herbicide Resistance Testing in Different Weed Species
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Evolution of Glyphosate-Resistant Weeds.

Yousoon Baek1, Lucas K Bobadilla1, Darci A Giacomini1

  • 1Department of Crop Sciences, University of Illinois, Urbana, IL, USA.

Reviews of Environmental Contamination and Toxicology
|May 1, 2021
PubMed
Summary

Glyphosate-resistant crops have led to 48 weed species evolving resistance through various genetic mechanisms. Understanding these evolution pathways is crucial for effective weed management strategies.

Keywords:
EPSPSEvolutionGlyphosateHerbicide resistanceResistance mechanismsWeed management

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Area of Science:

  • Agricultural Science
  • Plant Biology
  • Genetics

Background:

  • Widespread use of glyphosate-resistant crops has increased reliance on glyphosate for weed control.
  • This reliance has created strong selective pressure for the evolution of herbicide-resistant weeds.

Purpose of the Study:

  • To review the diverse mechanisms of glyphosate resistance in weeds.
  • To discuss the evolutionary processes driving the emergence of these resistant weed populations.
  • To examine the impact of glyphosate-resistant weeds on agricultural management practices.

Main Methods:

  • Literature review of scientific publications on glyphosate resistance.
  • Analysis of documented cases of glyphosate resistance evolution in weed species.
  • Synthesis of information on genetic mechanisms and their prevalence.

Main Results:

  • Currently, 48 weed species have evolved resistance to glyphosate.
  • Resistance mechanisms include target-site modifications (amino acid substitutions, gene duplication) and other less common pathways.
  • These mechanisms vary in complexity, with single, double, and triple mutations observed.

Conclusions:

  • The evolution of glyphosate resistance is a significant challenge in modern agriculture.
  • Diverse genetic mechanisms contribute to weed resistance, necessitating ongoing research and adaptive management.
  • Effective weed management strategies must address the impact of these resistant populations.